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Date Published: 28/09/2025
Abstract Views: 17
Views PDF: 12
DOI: https://doi.org/10.56535/jmpm.v50i7.1430
Issue
Vol. 50 No. 7 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 7 - 2025
Section
Articles
How to Cite
Nguyễn, B. H., Nguyễn, T. C., Trần, T. M., Nguyễn, H. C., Cấn, V. M., & Lê, D. C. (2025). NGHIÊN CỨU XÂY DỰNG MÔ HÌNH CHẤN THƯƠNG TỦY SỐNG BẰNG KẸP CLIP TRÊN THỰC NGHIỆM. Journal of Military Pharmaco-medicine, 50(7), 72-80. https://doi.org/10.56535/jmpm.v50i7.1430

NGHIÊN CỨU XÂY DỰNG MÔ HÌNH CHẤN THƯƠNG TỦY SỐNG BẰNG KẸP CLIP TRÊN THỰC NGHIỆM

Bá Hiếu Nguyễn1, , Trung Chức Nguyễn1, Thị Mai Trần1, Hữu Cảnh Nguyễn1, Văn Mão Cấn1, Duy Cương Lê2
1 Học viện Quân y
2 Bệnh viện Trung ương Quân đội 108

Main Article Content

Abstract

Objectives: To establish an experimental model of spinal cord injury (SCI) using the clip compression method in rats. Methods: 16 rats, divided into two groups: sham group (n = 8) and SCI group (n = 8). The SCI model was generated with a compressive force of 70g applied for 60 seconds at the T8 - T10 spinal cord level. Locomotor and sensory parameters were assessed using the Basso-Beattie-Bresnahan (BBB) locomotor scale, Rotarod test, the ladder rung walking test and Hot Plate test. Spinal cord tissues were harvested for histological examination. Results: On days 1, 2, 3, 7, 14, 21, and 28 post-injury, the BBB scores in the SCI group decreased compared to the sham group (p < 0.05). On days 7, 14, 21, and 28 post-injury, the Rotarod performance time in the SCI group decreased compared to the sham group (p < 0.001); the foot fault rate in the SCI group was higher than that in the sham group (p < 0.001); and the response time in the SCI group was longer than that in the sham group (p < 0.001). Histopathological analysis on days 14 and 28 post-injury revealed features of acute spinal cord injury. Conclusion: The SCI model was successfully established using a compressive force of 70g applied for 60 seconds at the T8 - T10 level in rats, similar to the characteristics of moderate to severe clinical SCI.

Article Details

Keywords

Spinal cord injury, Clip compression, Experimental models

References

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