KHẢO SÁT SỰ BIẾN ĐỔI NỒNG ĐỘ MICROALBUMIN NƯỚC TIỂU Ở NGƯỜI BỆNH CHẾT NÃO DO CHẤN THƯƠNG SỌ NÃO

Abstract

Objectives: To evaluate changes in urinary microalbumin concentration over time and determine the relationship between this index and acute kidney injury (AKI) in brain-dead patients due to traumatic brain injury (TBI). Methods: A retrospective, descriptive study was conducted on 63 patients diagnosed with TBI and confirmed brain death, admitted between January 2013 and January 2019 to the Anesthesia and Intensive Care Center, VietDuc University Hospital and the Intensive Care, Emergency, and Poison Control Center, Military Hospital 103. Results: Urinary microalbumin concentrations tend to increase progressively over time after brain death. At 12 hours, patients with AKI had significantly higher microalbumin concentrations compared to those without AKI (p < 0.05). ROC analysis at 12 hours showed an AUC of 0.671 for microalbumin in predicting AKI, with a sensitivity (Se) of 85.7% and specificity (Sp) of 48.6%. Conclusion: Urinary microalbumin concentration in brain-dead patients due to TBI tended to increase gradually with the progression of brain death, especially after 12 hours of brain death (p < 0.05). Urinary microalbumin concentration at 12 hours of brain death had predictive value for AKI in brain-dead patients with AUC = 0.671; Se: 0.857 and Sp = 0.486 (p < 0.05).