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Date Published: 10/12/2025
Abstract Views: 18
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DOI: 10.56535/jmpm.v50si4.1385
Issue
Vol. 50 No. si4 (2025): JOURNAL OF MILITARY PHARMACO-MEDICINE - SPECIAL ISSUE 12/2025
Section
Special issue celebrating the 75th anniversary of Military Hospital 103
How to Cite
Nguyen, T. S., Nguyen, T. P. N., Nguyen, M. N., Le, D. T., Nguyen, H. T., Le, T. H. V., Dao, N. H., Dinh, T. H., & Vu, H. T. (2025). STUDY ON THE RELATIONSHIP OF MATERNAL SERUM CORTISOL AND LOW-GRADE INFLAMMATION INDICES WITH SOME PREECLAMPSIA RISKS AND FETAL GROWTH INDICES BY ULTRASOUND IN FIRST-TIME DIAGNOSED GESTATIONAL DIABETES MELLITUS. Journal of Military Pharmaco-medicine, 50(si4), 646-653. https://doi.org/10.56535/jmpm.v50si4.1385

STUDY ON THE RELATIONSHIP OF MATERNAL SERUM CORTISOL AND LOW-GRADE INFLAMMATION INDICES WITH SOME PREECLAMPSIA RISKS AND FETAL GROWTH INDICES BY ULTRASOUND IN FIRST-TIME DIAGNOSED GESTATIONAL DIABETES MELLITUS

Tien Son Nguyen1, , Thi Phi Nga Nguyen1, Minh Nui Nguyen1, Dinh Tuan Le1, Huy Thong Nguyen1, Thi Hong Van Le2, Nguyen Hung Dao3, Trung Hoa Dinh3, Hien Trinh Vu3
1 Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University
2 Department of Obstetrics and Gynecology, Military Hospital 103, Vietnam Military Medical University
3 National Hospital of Endocrinology

Main Article Content

Abstract

Objectives: To describe serum cortisol and low-grade inflammation (LGI) in first-time diagnosed gestational diabetes mellitus (GDM) and investigate the relationship of maternal serum cortisol and LGI with maternal preeclampsia risks and fetal growth indices by ultrasound in first-time diagnosed GDM.Methods: A cross-sectional, descriptive study was conducted on 248 first-time diagnosed GDM in Military Hospital 103 and National Hospital of Endocrinology from 2015 to 2024. Results: Serum cortisol, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were significantly higher in GDM compared with the normal glucose-tolerant (NGT) group. LGI but not cortisol levels were associated with percentage of age > 35, systolic blood pressure, and BMI. While maternal cortisol positively correlated with abdominal circumference - AC (r = 5.5) and estimated fetal weight - EFW (r = 85.3) of the fetus, NLR negatively correlated with EFW (B = -64.4) after adjusting for maternal BMI and FPG. PLR negatively correlated with fetal biparietal diameter - BPD (B = -0.02), AC (B = -0.06), EFW (B = -1.1), and head circumference - HC (B = -0.06), with p < 0.05. Conclusion: Serum cortisol, LGI, and fetal growth indices in GDM were higher than those in NGT pregnancy.

Keywords

Gestational diabetes mellitus, Cortisol, Low-grade inflammation, Fetal ultrasound index, Preeclampsia risk

Article Details

References

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