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Date Published: 10/12/2025
Abstract Views: 13
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DOI: 10.56535/jmpm.v50si4.1380
Issue
Vol. 50 No. si4 (2025): JOURNAL OF MILITARY PHARMACO-MEDICINE - SPECIAL ISSUE 12/2025
Section
Special issue celebrating the 75th anniversary of Military Hospital 103
How to Cite
Tran, D. H., Thai, K. T., Bui, K. C., & Le, T. S. (2025). CLINICAL SIGNIFICANCE OF PREOPERATIVE CEA, CA19-9, AND CA72-4 LEVELS IN PREDICTING OUTCOMES AFTER CURATIVE RESECTION FOR GASTRIC ADENOCARCINOMA. Journal of Military Pharmaco-medicine, 50(si4), 54-62. https://doi.org/10.56535/jmpm.v50si4.1380

CLINICAL SIGNIFICANCE OF PREOPERATIVE CEA, CA19-9, AND CA72-4 LEVELS IN PREDICTING OUTCOMES AFTER CURATIVE RESECTION FOR GASTRIC ADENOCARCINOMA

Doanh Hieu Tran1, Khac Thao Thai1, Khac Cuong Bui2, Thanh Son Le1,
1 Bệnh viện Quân y 103, Học viện Quân y
2 Khoa Y học thực nghiệm, Bệnh viện Trung ương Quân đội 108

Main Article Content

Abstract

Summary

Objectives: To evaluate the prognostic significance of CEA, CA19-9, and CA72-4 levels in predicting outcomes following curative surgery for gastric carcinoma. Subjects and methods: A descriptive study was conducted on 68 patients diagnosed with gastric carcinoma who underwent gastrectomy with lymphadenectomy at the Department of Gastrointestinal Surgery, 103 Military Hospital, from July 2021 to December 2023. Results: Serum levels of CEA, CA19-9, and CA72-4 tended to be higher in tumors with more extensive invasion (p = 0.636, 0.140, and 0.004, respectively), in cases with lymph node metastasis compared to those without (p = 0.228, 0.084, and 0.066, respectively), and in patients with advanced disease stages (p = 0.750, 0.029, and 0.012, respectively). In both univariate and multivariate prognostic models, only CA72-4 demonstrated a statistically significant association with poorer postoperative survival outcomes (p < 0.05). Conclusion: Although elevated levels of CEA, CA19-9, and CA72-4 were observed in more advanced stages of gastric cancer, only CA72-4 showed a statistically significant association, indicating its potential as a prognostic biomarker for unfavorable outcomes after curative surgery in patients with gastric carcinoma.

Keywords

Gastric carcinoma, CEA, CA 19-9, CA 72-4, Predicting outcome, Curative resection

Article Details

References

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