ĐÁNH GIÁ TÁC DỤNG ĐIỀU TRỊ XƠ GAN CỦA CAO CHIẾT CÂY AN XOA (Helicteres hirsuta Lour.) TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objectives: Evaluate the therapeutic effect on cirrhosis of methanol extract (HHM) and water extract (HHW) from the aerial part of the Helicteres hirsuta L. Methods: Wistar rats were experimentally induced with liver cirrhosis using CCl₄ according to the model of Gao et al over 12 weeks. After the induction of cirrhosis, experimental animals were divided into six groups: Groups 1, 2, and 3 received distilled water 10 ml/kg/day; group 1 (control group): no cirrhosis induction; group 2: CCl₄ injection was discontinued;  group 3: CCl₄ injection was continued; group 4 (silymarin control) received oral silymarin at 0,2g/kg/day; group 5 (HHW): received oral HHW at 1,34g/kg/day; group 6 (HHM): received oral HHM at 1,3g/kg/day (CCl₄ injection was discontinued in groups 4, 5, and 6). The treatment phase lasted for 12 weeks. Results: The groups of rats received HHM extract (1,34 g/kg) and HHW extract (1,3 g/kg) showed alleviated liver dysfunction symptoms, prolonged survival time, and a significant reduction in the area of fibrotic bands in liver histology (15.14 ± 3.65% with HHW and 15.11 ± 4.38% with HHM) compared to the hepatotoxic control group (23.07 ± 5.41% and 24.78 ± 5.45%, p<0.01 and p<0.001). Conclusion: The HHW and HHM extracts lessen the severity of liver cirrhosis and prolong the survival time in experimental animals.