ASSESSMENT OF VENTILATORY PULMONARY FUNCTION IN PATIENTS WITH METABOLIC SYNDROME

Ngoc Thao Pham1, , Van Quan Le1
1 Bộ môn - Khoa Chẩn đoán chức năng, Bệnh viện Quân y 103, Học viện Quân y

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Abstract

Objectives: To investigate the characteristics of ventilatory pulmonary function and their associations with some clinical and subclinical characteristics in patients with metabolic syndrome according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) 2005 criteria. Methods: A cross-sectional descriptive study was conducted on 103 patients who were diagnosed with metabolic syndrome according to NCEP-ATP III-2005 criteria and had pulmonary ventilation measured from July 2024 to April 2025 at the Functional Diagnosics Department, Military Hospital 103. Pulmonary ventilation function parameters, including forced vital capacity (FVC%), FEV1/FVC (Gaensler scale), and forced expiratory flow between 25% to 75% of FVC (FEF 25 - 75%), were collected. Results:The proportion of patients with obstructive ventilatory impairment (FEV1/FVC < 70%) and restrictive ventilatory disorders (FVC < 80%) was 16.5% and 21.4% respectively. The proportion of patients with mixed obstructive and restrictive lung disease was 11.7%. The FVC index was negatively and significantly associated with age, smoking status, and blood glucose levels. Similarly, the BMI index was negatively and significantly associated with the FEF 25 - 75% index. Conclusion: Changes in pulmonary ventilation function were observed in patients with metabolic disorders. Among them, age, smoking, blood glucose concentration, and BMI index were factors related to pulmonary ventilation function in patients with metabolic disorders.

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References

1. Ford ES, Cunningham TJ, Mercado CI. Lung function and metabolic syndrome: Findings of National Health and Nutrition Examination Survey 2007 - 2010. J Diabetes. 2014; 6(6):603-613.
2. Dang AK, Le HT, Nguyen GT, Mamun AA, Do KN, Thi Nguyen LH, et al. Prevalence of metabolic syndrome and its related factors among Vietnamese people: A systematic review and meta-analysis. Diabetes Metab Syndr. 2022 Apr; 16(4):102477.
3. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, et al. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112(17):2735-2752.
4. Shafiq I, Uzbeck MH, Zoumot Z, Abuzakouk M, Parappurath N, Wahla AS. Correlation between reduced FEF 25 - 75% and a positive methacholine challenge test in adults with nonobstructive baseline spirometry. Pulm Med. 2021; 2021:6959322.
5. Bhakta NR, McGowan A, Ramsey KA, Borg B, Kivastik J, Knight SL, et al. European Respiratory Society/American Thoracic Society technical statement: Standardisation of the measurement of lung volumes, 2023 update. Eur Respir J. 2023; 62(4):2201519.
6. Backman H, Eriksson B, Hedman L, Stridsman C, Jansson SA, Sovijärvi A, Lindberg A, et al. Restrictive spirometric pattern in the general adult population: Methods of defining the condition and consequences on prevalence. Respir Med. 2016; 120:116-123.
7. Murtagh E, Heaney L, Gingles J, Shepherd R, Kee F, Patterson C, et al. Prevalence of obstructive lung disease in a general population sample: The NICECOPD study. Eur J Epidemiol. 2005; 20(5):443-453.
8. Molina-Luque R, Molina-Recio G, de-Pedro-Jiménez D, Álvarez Fernández C, García-Rodríguez M, Romero-Saldaña M. The impact of metabolic syndrome risk factors on lung function impairment: Cross-sectional study. JMIR Public Health Surveill. 2023; 9:e43737.
9. Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, et al. Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. Intern Med. 2012; 51:2291-2297.
10. Choi JH, Park S, Shin YH, Kim MY, Lee YJ. Sex differences in the relationship between metabolic syndrome and pulmonary function: The 2007 Korean National Health and Nutrition Examination Survey. Endocr J. 2011; 58:459-465.