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EVALUATION OF ACUTE AND SUBCHRONIC TOXICITY OF HOAT LAC CHI THONG LIQUID EXTRACT IN EXPERIMENTAL ANIMALS
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Abstract
Objective: To evaluate the acute and sub-chronic toxicity of Hoat Lac Chi Thong liquid extract.
Methods: The oral acute toxicity was studied in Swiss mice by the Litchfield–Wilcoxon method. The oral sub-chronic toxicity was studied in Wistar rats, following the guidelines of the WHO, the Ministry of Health.
Results: The LD₅₀ could not be determined following oral administration in Swiss mice, even at the maximum administrable dose of 300 ml/kg body weight. Subchronic toxicity for 90 days: general condition, hematological, biochemical and histological indices of liver, spleen and kidney of rats between control group and 2 groups using drug had no difference (p > 0.05).
Conclusion: Hoat Lac Chi Thong liquid extract does not cause acute toxicity; and is safe at the dose levels used in the 90-day subchronic toxicity evaluation in Wistar rats.
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Keywords
Hoat Lac Chi Thong, acute toxicity, sub-chronic toxicity
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