ĐẶC ĐIỂM MÔ BỆNH HỌC VÀ KẾT QUẢ VI PHẪU THUẬT THU TINH TRÙNG TỪ TINH HOÀN Ở BỆNH NHÂN KLINEFELTER VÔ TINH KHÔNG KHẢM

Abstract

Objectives: Describe clinical and paraclinical characteristics of Klinefelter azoospermia patients, evaluate the ability to retrieve sperm using micro TESE in Klinefelter azoospermia patients.

Subjects and methods: Descriptive, prospective study on 67 KS azoospermia patients (47, pure XXY) treated at three assisted reproductive facilities from 05/2023–05/2025. Clinical, endocrine, testicular volume, histopathological parameters and micro TESE results were collected and analyzed using descriptive statistics.

Results: Mean age 34.1 ± 4.5 years; infertility duration 5.0 ± 4.4 years; BMI 23.1 ± 2.6 kg/m². Average FSH and LH were 37.2 ± 18.9 mIU/mL and 23.2 ± 8.2 mIU/mL, respectively; Testosterone 7.0 ± 5.1 ng/mL. Bilateral testicular volume was approximately 1.5 mL. Histopathology showed “only Sertoli cells” accounting for 46.3%, hyaline sclerosis 19.4%, spermatogenesis arrest 13.4% and spermatogenesis failure 20.9%. Micro TESE successfully collected sperm in 14/67 patients (20.9%).

Conclusion: Azoospermic KS patients in Vietnam have the main histopathological feature of “only Sertoli cells” syndrome. The success rate of sperm retrieval by micro TESE is 21%, this technique provides the opportunity for biological fatherhood and should be indicated early also confirms the effectiveness of micro TESE in treating non-obstructive azoospermic patients with Klinefelter syndrome.