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Date Published: 28/08/2025
Abstract Views: 38
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DOI: https://doi.org/10.56535/jmpm.v50i6.1319
Issue
Vol. 50 No. 6 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 6 - 2025
Section
Articles
How to Cite
Hoang, V. N., Pham, T. H., Bui, T. T. H., Bui, T. B. V., Pham, A. H., Nguyen, V. T., Vu, T. A., & Tran, B. H. (2025). SAFETY OF THE HOAN LUC KHANG CAPSULE IN EXPERIMENTAL ANIMALS. Journal of Military Pharmaco-medicine, 50(6), 9-18. https://doi.org/10.56535/jmpm.v50i6.1319

SAFETY OF THE HOAN LUC KHANG CAPSULE IN EXPERIMENTAL ANIMALS

Hoang Van Nghia1, Pham Thai Ha2, Bui Thi Thu Ha3, Bui Thi Bich Van3, Anh Hoa Pham4, Nguyen Van Thinh5, Vu Tuan Anh5, Tran Ba Hieu5,
1 Khoa Đông y, Bệnh viện Quân y 103, Học viện Quân y
2 Học viện Y Dược học Cổ truyền Việt Nam
3 Viện Đào tạo Dược, Học viện Quân y
4 Khoa Y Dược Cổ truyền - Phục hồi chức năng, Bệnh viện Đa khoa khu vực Đồng Hới
5 Viện Nghiên cứu Y Dược học Quân sự, Học viện Quân y

Main Article Content

Abstract

Objectives: To assess the safety of the Hoan luc khang capsule in experimental animals. Methods: Acute toxicity was assessed in mice according to the Litchfield-Wilcoxon method and World Health Organization (WHO) guidelines. Subchronic toxicity was evaluated in rats using the Organization for Economic Co-operation and Development (OECD) and the Vietnam Ministry of Health guidelines. Results: At a maximal dose of 35 g/kg/day, which is 50 times more than the anticipated effective dose, no LD50 of Hoan luc khang capsules was detected in mice. Taking Hoan luc khang soft capsules at three dose levels of 390, 780, and 1560 mg/kg/day continuously for 42 days had no effect on the rat's weight, general health, histopathological images, or biochemical and hematological indicators. Conclusion: Hoan luc khang capsules are safe and do not produce any acute or subchronic toxicity in experimental animals.

Article Details

Keywords

Hoan luc khang, Acute toxicity, Subchronic toxicity

References

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