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ĐÁNH GIÁ TÌNH TRẠNG NHIỄM TRÙNG HUYẾT VÀ TÍNH KHÁNG KHÁNG SINH CỦA MỘT SỐ VI KHUẨN THƯỜNG GẶP Ở BỆNH NHÂN BẠCH CẦU CẤP ĐIỀU TRỊ HÓA CHẤT
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Abstract
Objectives: Evaluation of bloodstream infection and antibiotic resistance patterns of common bacteria in patients with acute leukemia undergoing chemotherapy at Department of Clinical Hematology, 108 Military Central Hospital. Subject and Method: This is a retrospective, case series study involving 44 admissions in patients with acute leukemia undergoing chemotherapy who had positive blood culture. The study was conducted at the Department of Clinical Hematology, 108 Military Central Hospital from January 2022 to February 2025. Results: The incidence of bloodstream infection among acute leukemia patients receiving chemotherapy was 9.3%. Gram-negative bacteria were the predominant pathogens, accounting for 86.4%, with K. pneumoniae (43.2%) and E. coli (34.1%) being the most common. The rate of multidrug-resistant (MDR) bacterial infections was 76.2%, all of which were caused by Gram-negative bacteria, primarily K. pneumoniae (53.1%) and E. coli (43.6%). Gram-positive bacteria accounted for 9.1%, mainly Staphylococcus aureus, which was sensitive to vancomycin and linezolid. Candida tropicalis was isolated in 4.5% of cases and was sensitive to caspofungin and micafungin. The bloodstream infcetion-related mortality rate was 20.5%. Conclusions: The incidence of bloodstream infection among acute leukemia patients receiving chemotherapy was 9.3%. Gram-negative bacteria were the most common causative agents (86.4%), with K. pneumoniae and E. coli being the predominant multidrug-resistant pathogens.
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Keywords
Acute leukemia, bloodstream infection, Gram-negative bacteria, antibiotic resistance, Klebsiella pneumoniae, Escherichia coli.
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