ĐÁNH GIÁ ẢNH HƯỞNG CỦA PHỦ HA LÊN TÍNH TỰ TIÊU CỦA VẬT LIỆU MG ZK60 TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Objective: To evaluate the biodegradation rate of HA coated ZK60 materials. Subjects and Research Methods: Healthy white rabbits were randomly divided into 6 groups: Group 1 (n=28) was implanted with HA-coated Mg ZK60 screws; Group 2 (n=16) was implanted with HA-coated ZK60 plates; Group 3 (n=16) was implanted with uncoated ZK60 plates; Group 4 (n=28) was implanted with HA-coated Mg ZK60 screws; Group 5 (n=28) was implanted with uncoated ZK60 screws; Group 6 (n=28) was implanted with titanium screws. The rabbits in each group had screws implanted into the femurs, which had undergone a bone defect model. X-ray imaging was performed before surgery, and at 3, 7, 30, 60, 90, and 180 days post-surgery to analyze the shape of the material and the formation of gas bubbles around the implant. Results: In the HA-coated ZK60 group, the material’s disk shape was round, clearly visible on the X-ray, with fewer gas bubbles appearing, and those that did were smaller in size (less than 4 times the size of the material). In the uncoated ZK60 group, the material’s disk shape was irregular, and the screws were less visible on the X-ray, with larger gas bubbles (greater than 4 times the size of the material). Conclusion: HA coating slows down the biodegradation process of ZK60 material.