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THE RELATIONSHIP BETWEEN BLOOD LACTATE LEVEL AT ADMISSION AND OUTCOMES IN PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY
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Abstract
Abstract
Objectives: To investigate the relationship between blood lactate at admission with the treatment outcome of patients with severe traumatic brain injury (TBI).
Methods: A prospective, cohort study was conducted on 68 patients with severe TBI who were treated at the Intensive Care Unit (ICU), Military Hospital 105. Data were entered into the research medical records and processed according to statistical algorithms. Results: The average age of patients with severe TBI was 44.71 ± 19.93, the GCS score at admission was 6.59 ± 1.67, and the average lactate concentration at admission was 3.92 ± 1.76 mmol/L. Blood lactate at admission in the death group was higher than that of the survival group; the difference was statistically significant (p < 0.05). Blood lactate concentration had a moderate positive correlation with the length of hospital stay (r = 0.431) and the length of ICU stay (r = 0.458), with p < 0.05. The area under the curve (AUC) for predicting mortality based on blood lactate concentration at admission was 0.814. Conclusion: Blood lactate at admission is an important biomarker with prognostic significance for mortality in patients with severe traumatic brain injury.
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Keywords
severe traumatic brain injury, Lactate, prognosis
References
2. N Carney, AM Totten, et al. Guidelines for the management of severe traumatic brain injury, Fourth Edition. Neurosurgery. 2017; 80(1):6-15.
3. Nguyễn Đình Hiệp, Đỗ Ngọc Sơn, Nguyễn Văn Hương và CS. Đặc điểm lâm sàng, cận lâm sàng, hình ảnh học và kết quả điều trị bệnh nhân chấn thương sọ não nặng tại Khoa Hồi sức Tích cực ngoại khoa, Bệnh viện Hữu nghị Đa khoa Nghệ An. Tạp chí Y học Việt Nam. 2024; 2:240-244.
4. R Wang, M He, F Qu, et al. Lactate albumin ratio is associated with mortality in patients with moderate to severe traumatic brain injury. Front Neurol. 2022; 13:662385.
5. Phạm Nguyên Hoàng, Nguyễn Trung Kiên, Nguyễn Quang Huy và CS. Nghiên cứu giá trị tiên lượng tử vong sớm của thang phân loại Marshall và điểm Rotterdam ở bệnh nhân chấn thương sọ não nặng. Tạp chí Y học Việt Nam. 2022; 1A:128-132.
6. JH Lee, D Lee, BK Lee, et al. The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury. Ulus Travma Acil Cerrahi Derg. 2023; 29(7):752-757.
7. TC Glenn, DF Kelly, WJ Boscardin, et al. Energy dysfunction as a predictor of outcome after moderate or severe head injury: Indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab. 2003; 23(10):1239-1250.
8. Bharti Sharma, Winston Jiang, Yashoda Dhole, et al. Lactate is a strong predictor of poor outcomes in patients with severe traumatic brain injury. 2024; (12):2778.
9. Yu-Mei Wang, Ning Zhu, Yi-Min Zhou, et al. The combination of arterial lactate level with GCS-pupils score to evaluate short term prognosis in traumatic brain injury: A retrospective study. BMC Neurology. 2022; 22(1):430.