CHARACTERISTICS OF VITAMIN D DEFICIENCY AND ASSOCIATED FACTORS IN PATIENTS WITH SEVERE BURNS
Main Article Content
Abstract
Objectives: To assess the prevalence of vitamin D deficiency and associated factors in patients with severe burns. Methods: A longitudinal prospective descriptive study was conducted on 88 patients (aged ≥ 18 years) with severe burns admitted to the Intensive Care Unit, Le Huu Trac National Burn Hospital, from March 2023 to February 2025. Results: The prevalence of vitamin D deficiency at hospital admission was 71.6%, including 38.6% with severe deficiency. The prevalence increased markedly on day 7 (88%) and remained persistently high on day 28 post-burn (85.4%). Serum 25(OH)D levels at admission were negatively correlated with total burn surface area (rho = -0.32; p = 0.002), deep burn surface area (rho = -0.45; p = 0.001), while showing positive correlations with serum albumin levels (rho = 0.41; p = 0.001) and total protein levels (rho = 0.37; p = 0.001). Deep burn surface area was independently associated with serum 25(OH)D levels at admission (β = -0.27; p = 0.04). Conclusion: Vitamin D deficiency was highly prevalent in patients with severe burns at hospital admission and persisted throughout the post-burn period. Deep burn surface area was independently associated with serum 25(OH)D levels at admission.
Keywords
Severe burns, Vitamin D deficiency, Associated factors
Article Details
References
2. Krajewski A, Piorun K, Maciejewska- Markiewicz D. 25-hydroxycholecalciferol concentration is associated with protein loss and serum albumin level during the acute phase of burn injury. Nutrients. 2020;12(9):2780. doi:10.3390/nu12092780
3. Cho YS, Seo CH. The association between vitamin D levels and burn factors in different burn types. Burns & Trauma. 2020;8:tkaa018.
4. Chen KW, Chen CW, Yuan KC, et al. Prevalence of vitamin D deficiency and associated factors in critically ill patients: a multicenter observational study. Front Nutr. 2021;8:768804.
5. Madarshahian D, Kaur A, Parekh J, Wilson Y. Vitamin D deficiency and clinical outcomes in adult burn patients: a systematic review and meta-analysis. Cureus. 2025;17(12):e99123.
6. Zavala S, Pape KO, Walroth TA. Vitamin D deficiency is associated with increased length of stay after acute burn injury: a multicenter analysis. J Burn Care Res. 2024;45(3):728-32.
7. Nguyen HT, von Schoultz B, Nguyen TV, et al. Vitamin D deficiency in northern Vietnam: prevalence, risk factors and associations with bone mineral density. Bone. 2012;51(6):1029-34.