BÁO CÁO CA BỆNH: ĐỒNG MẮC BẠCH CẦU TỦY MẠN CHUYỂN BẠCH CẦU CẤP DÒNG TỦY VÀ U LYMPHO KHÔNG HODGKIN TẾ BÀO T

Abstract

We report a case of coexistence of acute myeloid leukemia and T-cell non-Hodgkin lymphoma. This is a rare case of concurrent hematologic malignacies in the same patient. The diagnostic process and treatment planning were challenging. Initially, the patient was diagnosed with accelerated-phase chronic myeloid leukemia with positive BCR-ABL. The patient was treated with imatinib, resulting in improved blood parameters, however, lymphadenopathy persisted. Lymph node biopsy with HE staining and immunohistochemistry confirmed a diagnosis of T cell Non-Hodgkin lymphoma. The patient subsequently received induction chemotherapy with the 3+7 regimen, followed by three cycles of HiDAC consolidation therapy. Hematologic evaluation confirmed complete remission. To date, no standardized treatment protocol has been established for patients with concurrent diagnoses of these two malignacies. Allogeneic stem cell transplantation is considered the preferred option for a potential cure. However, due to the lack of a suitable sibling stem cell donor, the current treatment for this patient remains challenging.