ĐẶC ĐIỂM MỘT SỐ CHỈ SỐ HUYẾT HỌC VÀ THÀNH PHẦN HEMOGLOBIN CỦA NGƯỜI MANG GENE BETA THALASSEMIA TẠI BỆNH VIỆN PHỤ SẢN HÀ NỘI

Abstract

Objective: to describe HBB gene variants  in beta Thalassemia carriers and to evaluate the red blood cell indices characteristics in beta thalassemia carriers. Methods: Cross-sectional descriptive study: 155 subjects with beta Thalassemia gene variants, red blood cell indices  and hemoglobin electrophoresis at Hanoi Obstetrics and Gynecology  Hospital. Results: Among those with HBB gene variants, 22.6% also inherit α thalassemia. Mean MCV, MCH values were 76.4±3.37fl and 25.1±1.26pg in HbE carriers. Mean MCV, MCH values were 63.2±3.08fl and 20.1±1.31pg in β0/β or β+/β carriers. Using red blood indices and electrophoresis, it is difficult to distinguish between β-thalassemia carriers and both βα-thalassemia carriers, except HbE heterozygotes who also inherit α⁰ thalassemia have a marked decrease of  %HbE<20%. Conclusion: MCV; MCH values were directly related to HBB gene mutations. It is necessary to test for α-thalassemia gene mutations in β-thalassemia carriers.