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Date Published: 28/03/2025
Abstract Views: 23
Views PDF: 12
DOI: https://doi.org/10.56535/jmpm.v50i3.1150
Issue
Vol. 50 No. 3 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 3 - 2025
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Articles
How to Cite
Đỗ, L. H., Nghiêm, Đ. T., Nguyễn, V. B., Quản, T. N., Nguyễn, P. L., Nguyễn, V. Đ., Nguyễn, Đ. Ứ., & Đào, T. T. (2025). PROGNOSIC VALUE OF PLASMA cf EBV DNA CONCENTRATIONS IN NASOPHARYNGEAL CARCINOMA PATIENTS. Journal of Military Pharmaco-medicine, 50(3), 51-60. https://doi.org/10.56535/jmpm.v50i3.1150

PROGNOSIC VALUE OF PLASMA cf EBV DNA CONCENTRATIONS IN NASOPHARYNGEAL CARCINOMA PATIENTS

Lan Hương Đỗ1, , Đức Thuận Nghiêm2, Văn Ba Nguyễn2, Thành Nam Quản1, Phi Long Nguyễn1, Văn Đăng Nguyễn3,4, Đình Ứng Nguyễn5, Thùy Trang Đào5
1 Bộ môn - Khoa Tai Mũi Họng, Bệnh viện Quân y 103, Học viện Quân y
2 Học viện Quân y
3 Khoa xạ Đầu, cổ, Bệnh viện K cơ sở Tân Triều
4 Bộ môn Ung thư, Đại học Y Hà Nội
5 Trung tâm Sinh học phân tử, Viện Nghiên cứu Y Dược học Quân sự, Học viện Quân y

Main Article Content

Abstract

Objective: To evaluate the prognostic value for survival outcomes of plasma EBV DNA concentration in nasopharyngeal carcinoma (NPC) patients. Methods: A longitudinal, descriptive investigation study on 84 patients’ undifferentiated NPC stages III-IVa, at Tan Trieu K Hospital from August 2021 to August 2024. Results:  The best cut-off value predicting recurrence/metastasis of EBV6 was 1.5 copies/ml and EBV12 was 9.0 copies/ml, p<0.005. The rate of disease-free survival (DFS) and overall survival (OS) in the group below the cut-off was statistically higher than that in the group above the cut-off (p<0.005). Multivariate analysis showed that EBV6 and EBV12 were independent prognostic factors for DFS and OS. DFS prediction, EBV6 (1.5 copies/ml) had HR=9.585 (95%CI=3,124-29,411) p<0.0001, EBV12 (9.0 copies/ml) had HR=10.359 (95%CI = 2.528-42.442) p=0.001. OS prediction, EBV12 (9.0 copy/ml) had HR=5.933 (95%CI = 1.141-30.852) p< 0.05, EBV6 (1.5 copy/ml) had HR=5.517 (95%CI = 1.604-18.975) p< 0.05. Conclusion: Optimal EBV6 threshold of 1.5 copy/ml and optimal EBV12 threshold of 9.0 copy/ml are independent prognostic factors for DFS and OS.

Article Details

Keywords

nasopharyngeal carcinoma, plasma cf EBV DNA concentration, prognosis, disease-free survival, overall survival

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