ĐẶC ĐIỂM NHẬN THỨC Ở NGƯỜI BỆNH PARKINSON THEO THANG ĐIỂM MoCA TẠI BỆNH VIỆN LÃO KHOA TRUNG ƯƠNG

Thanh Bình Nguyễn1,2, Phước Đông Hà3, , Tấn Dũng Nguyễn3,4
1 Trường Đại học Y Hà Nội
2 Bệnh viện Lão khoa Trung ương
3 Bệnh viện C Đà Nẵng
4 Trường Đại học Kỹ thuật Y Dược Đà Nẵng

Main Article Content

Abstract

COGNITIVE CHARACTERISTICS IN PARKINSON’S DISEASE PATIENTS USING THE MOCA SCALE AT THE NATIONAL GERIATRIC HOSPITAL


Abstract


Objective: To evaluate cognitive characteristics in patients with Parkinson's disease using the MoCA scale and identify related factors. Methods: A cross-sectional descriptive study was conducted on 113 patients with Parkinson's disease who were examined, treated and assessed cognitive function using the MoCA test at the National Geriatric Hospital from January 2024 to August 2024. Results: Among the 113 patients with Parkinson's disease studied, 75 patients (66.4%) had a MoCA score below 26. The average MoCA score for the patients was 21.82 ± 4.72. The MoCA score was significantly lower in patients aged 60 and older, those with lower educational levels, and those with manual labor occupations (p < 0.001). MoCA scores showed a strong negative correlation with the duration of Parkinson's disease (r = - 0.763, p < 0.001). MoCA scores were also strongly negatively correlated with the MDS-UPDRS (III) Off - stage scores (r = - 0.868, p < 0.001). Conclusion: The rate of cognitive decline, as measured by the MoCA score, in patients with Parkinson's disease in the study is quite high, accounting for 66.4%. Older age, low education level, manual labor occupations, long duration of Parkinson's disease, and severe motor dysfunction are factors associated with cognitive decline in patients with Parkinson's disease.


Keywords: Cognitive characteristics, Parkinson's disease, MoCA.

Article Details

References

1. Pringsheim T, Jette N, Frolkis A, Steeves TDL. The prevalence of Parkinson’s disease: A systematic review and meta‐analysis. Movement Disorders. 2014; 29(13):1583-1590. DOI: 10.1002/mds.25945.
2. Nguyễn Thanh Bình, Nguyễn Văn Hướng, Võ Hồng Khôi. Bệnh học Thần kinh (Giáo trình đào tạo Sau đại học). Hà Nội: Nhà xuất bản Y học; 2022.
3. Zhang Q, Aldridge GM, Narayanan NS, Anderson SW, Uc EY. Approach to cognitive impairment in Parkinson’s disease. Neurotherapeutics. 2020; 17(4):1495-1510. DOI: 10.1007/ s13311-020-00963-x.
4. Lucza T, Karádi K, Kállai J, et al. Screening mild and major neurocognitive disorders in Parkinson’s disease. Behav Neurol. 2015; 2015:983606. DOI: 10.1155/2015/983606.
5. Trần Thị Hồng Ny, Trần Công Thắng. Đặc điểm rối loạn thần kinh nhận thức ở bệnh nhân Parkinson. Tạp chí Y học Thành phố Hồ Chí Minh. 2017; 21(2):178.
6. Tysnes OB, Storstein A. Epidemiology of Parkinson’s disease. J Neural Transm. 2017; 124(8):901-905. DOI: 10.1007/s00702-017-1686-y.
7. Biundo R, Weis L, Bostantjopoulou S, et al. MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study. J Neural Transm (Vienna). 2016; 123(4):431-438. DOI: 10.1007/s00702-016-1517-6.
8. Jia X, Wang Z, Huang F, et al. A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: A cross-sectional study. BMC Psychiatry. 2021; 21(1):485. DOI: 10.1186/s12888-021-03495-6.
9. Kobak Tur E, Ari BC. Mild cognitive impairment in patients with Parkinson´s disease and the analysis of associated factors. Neurol Res. 2023; 45(12):1161-1168. doi:10.1080/01616412. 2023.2258038.
10. Patrick K, Cousins E, Spitznagel MB. Associations between cognitive screening performance and motor symptoms in Parkinson’s disease: A systematic review and meta-analysis. Dement Neuropsychol. 2024; 18.