Article Sidebar
Views PDF: 5
EFFECTS OF HIGH-FAT DIET CONSUMPTION ON ANXIETY – LIKE BEHAVIOR OF RAT
Main Article Content
Abstract
EFFECTS OF HIGH-FAT DIET CONSUMPTION ON ANXIETY – LIKE BEHAVIOR OF RAT
Objectives: To evaluate the anxiety – like behavior and fear behavior in obese rats by high-fat diet. Subjects and methods: The 24 white male rats, 8-9 weeks old, were divided into two groups of normal diet (n = 12) and high-fat diet group (n = 12). After model behaviors of rats were investigated from the 8 week to the 10 week following: the open-field test, Elevated plus maze test. Results: the behavior of rats in the open-field: travelled distance, moved time and number of entries in the central zone of rats in the normal diet group were longer significant than that in the high-fat diet group (p < 0,05). Travelled average speed in the central zone of rats in high-fat diet was also lower than that in the normal diet but It was not reach statiscicaly significant difference (p > 0,05). The behavior of rats in the elevated plus maze: rats in the high-fat diet in closed arms had more time spent and more arm entries with statistical significance than of rats in the normal diet group (p < 0.05). Meanwhile, the time spent and arm entries in the open arms and the central zone was less in the high-fat group than in the normal diet group (p < 0,05). Conclusion: rats fed a high-fat diet had increased anxious – related behaviors compared to rats fed a normal diet.
Article Details
Keywords
High-fat diet, behavior, anxiety, fear, rat
References
2. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9945):766-781.
3. H Çakmur. Obesity as a growing public health problem. Jan Oxholm Gordeladze (Ed.), Adiposity - epidemiology and treatment modalities. Chapter 2. Intech Open. 2017.
4. Lalanza JF, Caimari A, del Bas JM, et al. Effects of a post-weaning cafeteria diet in young rats: Metabolic syndrome, reduced activity and low anxiety-like behaviour. PLoS One. 2014; 9(1):85049.
5. Schroeder M, Shbiro L, Weller A. Enriched environment moderates obesity in genetically hyperphagic OLETF rats in a sex-dependent manner. ILAR e-Journal. 2011; 52:39-45.
6. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gomez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience. 2002; 112(4):803-814.
7. Nguyễn Thị Hoa, Phạm Minh Đàm, Cấn Văn Mão, Nguyễn Lê Chiến. Gây mô hình béo phì trên chuột cống bằng thức ăn giàu chất béo. Tạp chí Y học Việt Nam. 2020; 493(1):7-13.
8. Deal AW, Seshie O, Lenzo A, et al. High-fat diet negatively impacts both metabolic and behavioral health in outbred heterogeneous stock rats. Physiological Genomics. 2020; 52(9): 379-390.
9. Han J, Nepal P, Odelade A, et al. High-fat diet-induced weight gain, behavioral deficits, and dopamine changes in young C57BL/6J mice. Frontiers in Nutrition. 2021; 7:591161.
10. Lopresti AL, Drummond PD. Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment. Prog Neuro Psychopharmacol Biol Psychiatr. 2013; 45:92-99.