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Date Published: 28/01/2025
Abstract Views: 11
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DOI: https://doi.org/10.56535/jmpm.v50i1.1059
Issue
Vol. 50 No. 1 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 1 - 2025
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Articles
How to Cite
Nguyễn, P. H., Nguyễn, T. T. M., Ngụy , T. Đ., Trần , M. L., Ngô , T. D., Phan, T. L., & Lê, N. A. (2025). ANTIBODY RESPONSE AFTER COVID-19 VACCINATION IN HEMODIALYSIS PATIENTS AT HANOI NEPHROLOGY HOSPITAL. Journal of Military Pharmaco-medicine, 50(1), 121-130. https://doi.org/10.56535/jmpm.v50i1.1059

ANTIBODY RESPONSE AFTER COVID-19 VACCINATION IN HEMODIALYSIS PATIENTS AT HANOI NEPHROLOGY HOSPITAL

Phương Hoa Nguyễn1, Thị Thúy Mậu Nguyễn2, Thị Điệp Ngụy 3, Mai Linh Trần 1, Trung Dũng Ngô 4, Tùng Lĩnh Phan4, Ngọc Anh Lê1,
1 Trường Đại học Y Dược, Đại học Quốc gia Hà Nội
2 University of Medicine and Pharmacy, Vietnam National Univesity, Hanoi
3 Hanoi Nephrology Hospital
4 Bệnh viện Thận Hà Nội

Main Article Content

Abstract

Objectives: To determine the concentration of IgG antibodies against SARS-CoV-2 after vaccination and the related factors in hemodialysis patients. Methods: A cross-sectional descriptive study was conducted on 103 hemodialysis patients. The ELISA technique was used to quantify the concentration of IgG antibodies against the SARS-CoV-2 spike protein. Results: The number of patients with a positive response after receiving the 1st, 2nd, and 3rd doses of the SARS-CoV-2 vaccine was 95/103 patients (92.23%), 100/103 patients (97.09%), and 100/102 patients (98.04%), respectively. After each dose, the concentration of IgG antibodies against the SARS-CoV-2 spike protein increased significantly, with mean values of 51.85 U/ml, 122.47 U/ml, and 136 U/ml, respectively. BMI and comorbidities such as diabetes, hypertension, and dyslipidemia were factors that influenced antibody levels after vaccination. Factors like age, gender, and longer dialysis duration were not related to the antibody response after vaccination. Conclusion: After COVID-19 vaccination, the majority of hemodialysis patients showed a positive response, and antibody levels increased significantly after each dose. BMI, diabetes, hypertension, heart failure, and dyslipidemia were factors that influenced antibody levels post-vaccination.

Article Details

Keywords

SARS-CoV-2, COVID-19 vaccine, chronic kidney disease, hemodialysis

References

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