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Date Published: 28/01/2025
Abstract Views: 11
Views PDF: 5
DOI: https://doi.org/10.56535/jmpm.v50i1.1030
Issue
Vol. 50 No. 1 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 1 - 2025
Section
Articles
How to Cite
Ngô, M. Đ., Chu, A. T., Do, X. H., Nguyen, V. H., Nguyen, T. H., Nguyen, V. P., & Kheng, M. (2025). STUDY ON THE EFFECT OF UMBRAL CORD BLOOD PLATELET-RICH PLASMA ON THE PROLIFERATION AND MIGRATION OF SKIN FIBROBLASTS. Journal of Military Pharmaco-medicine, 50(1), 101-110. https://doi.org/10.56535/jmpm.v50i1.1030

STUDY ON THE EFFECT OF UMBRAL CORD BLOOD PLATELET-RICH PLASMA ON THE PROLIFERATION AND MIGRATION OF SKIN FIBROBLASTS

Duc NM1,2, , Tuan CA3, Hai DX4, Han DV5, Huong NT6, Phong NV7, Monysoksonvann Kheng8
1 Học viện Quân y
2 Bệnh viện Bỏng Quốc gia Lê Hữu Trác, Học viện Quân y
3 Le Huu Trac National Burn Hospital, Military Medical Academy
4 Vietnam Military Medical University
5 Le Huu Trac national Burn Hospital
6 Le Huu Trac National Burn Hospital
7 Hai Phong International Maternity and Pediatrics Hospital
8 Bệnh viện Quân y Trung ương 179 Campuchia

Main Article Content

Abstract

Objective: To evaluate the effects of human umbilical cord blood PRP at different concentrations on the morphology, proliferation and migration of human skin fibroblasts. Research method: A prospective study was conducted using 6 healthy umbilical cord blood samples with PRP extracted using the New-PRP Pro kit GeneWorld V.10. PRP at concentrations of 5%, 10%, 15%, and 20% was added to the culture medium and evaluated the morphology, proliferation and migration of human skin fibroblasts. Results: PRP at all concentrations stimulated fibroblast proliferation and migration better than the control group, with normal, healthy fibroblast morphology, the concentration of 15% was the most effective; at a concentration of 20%, cells showed increased proliferation and migration compared to the study group, but there was also a phenomenon of cell aging and death. Conclusion: In vitro, Platelet-rich plasma from umbilical cord blood stimulates proliferation and migration of human dermal fibroblasts.

Article Details

Keywords

PRP, umbilical cord blood, proliferation, migration, fibroblasts

References

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