NGHIÊN CỨU XÂY DỰNG CÔNG THỨC BÀO CHẾ KEM BÔI DA COBRATOFOR ĐỂ GIẢM ĐAU, CHỐNG VIÊM TẠI CHỖ

Abstract

Abstract

Objective: To develop a formulation for Cobratofor topical cream containing cobra venom, methyl salicylate, menthol, camphor, peppermint oil, and cinnamon oil. Methods: The cream was formulated using a direct emulsification method, establishing the formulation through surveys on the oil phase and emulsifiers, as well as the ratio of the oil phase and permeation enhancers. The cream formulation was evaluated for properties, pH, stability after centrifugation, thermal cycling stability, physical stability, and permeation through mouse skin in vitro. Results: The suitable oil phase components for formulating Cobratofor topical cream are paraffin oil, olive oil, cetyl alcohol, cetostearylic alcohol, beeswax, and glycerin stearate. Both Tween 80 and sodium lauryl sulfate are suitable for cream formulation, with 1.5% Tween 80 providing the most stable cream with the best consistency. Isopropyl myristat and glycerin enhance the permeation of methyl salicylate through mouse skin. The most suitable formulation is CT18, which provides a permeation of methyl salicylate through mouse skin equivalent to the reference drug Deep Heat Rub Plus. Conclusion: A formulation for Cobratofor topical cream containing cobra venom, methyl salicylate, menthol, camphor, peppermint oil, and cinnamon oil has been developed.