MỘT SỐ VẤN ĐỀ LIÊN QUAN ĐẾN THUỐC TRONG KÊ ĐƠN THUỐC HÓA TRỊ TRÊN BỆNH NHÂN PHỤ UNG THƯ

Abstract

Objective: Identifying drug-related problems (DRPs) in clinical settings is crucial, particularly for patients with gynecologic cancers. This study aimed to detect DRPs associated with dosing regimens prescribed to these patients. Subjects and Methods: This retrospective descriptive study utilized data from medical records of patients treated with chemotherapy in the Gynecologic Oncology Department at the National Hospital of Obstetrics and Gynecology. The study focused on patients discharged between July 1, 2021, and June 30, 2022. DRP is determined according to the Ministry of Health guidance at Decision 3547/QĐ-BYT. Results: A total of 1,992 DRPs were detected across 4,347 prescriptions for 159 patients. These included 735 DRPs related to dosage (36.9%), 155 DRPs involving dilution solvents (7.8%), 382 DRPs related to infusion rates (19.2%), and 720 DRPs concerning treatment cycle intervals (36.1%). The majority of dosage-related DRPs were due to underdosing (77.4%), with most discrepancies between actual and theoretical doses falling within the 10-20% range (61.0%). Conclusion: Most of the DRPs identified were associated with dosage and administration, which are preventable. Enhancing clinical pharmacy services for gynecologic oncology patients is necessary to reduce DRPs and ensure the safety and effectiveness of chemotherapy.