NGHIÊN CỨU MỨC ĐỘ KHÁNG KHÁNG SINH CỦA KLEBSIELLA PNEUMONIAE PHÂN LẬP ĐƯỢC TỪ BỆNH NHÂN ĐIỀU TRỊ TẠI BỆNH VIỆN QUÂN Y 103 (2020 - 2022)

Abstract

Objectives: Determining the rate and analyzing the antibiotic resistance trend of K. pneumoniae isolated at 103 Military Hospital. Materials and methods: K. pneumoniae strains were isolated from patients treated at 103 Military Hospital from 2020 to 2022. Collect specimens and isolate bacteria according to WHO guidelines. Antibiotic susceptibility testing should be performed according to CLSI guidelines. Analyze antibiotic resistance and multi-resistance levels using Whonet2020 software; evaluate trends using the Cohran-Armitage trend test (Z, p). The recommended level of statistical significance is p < 0.05. Results: The total number of K. pneumoniae isolated was 702 strains. K. pneumoniae is more than 50% resistant to most antibiotics tested, including SXT 68.9%, NOR 68.77%; CIP 73.53%, CTX 69.97%; CAZ 69.13%; FEP 63.95%; AMC 67.58%. K. pneumoniae resistance increased over time with MEM; IMP; AN (p < 0.05). K. pneumoniae resistance to IMP from 53.99% (2020) to 65.57% (2022); MEM 56.08% (2020) to 68.38% (2022); AN 9.58% (2020) to 29.13% (2022). K. pneumoniae tended to increase MDR; XDR; and PDR throughout the study period.  There is a shift in the type of XDR bacteria replacing conventional MDR bacteria. Conclusions: K. pneumoniae has high resistance rates to most tested antibiotics. Attention should be paid to strictly implementing the management and use of antibiotics with this bacteria.