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Ngày xuất bản: 28/02/2023
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DOI: https://doi.org/10.56535/jmpm.v48i2.279
Số xuất bản
Tập 48 Số 2 (2023): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 2 - 2023
Chuyên mục
Bài báo
Trích dẫn bài báo
Phạm, H. K., Dương, Q. H., Nguyễn, Q. D., Trần, T. H. T., & Vũ, V. K. (2023). STUDY ON THE PRESENCE OF OIPA AND DUPA GENES OF HELICOBACTER PYLORI IN GASTRIC CANCER PATIENTS. Tạp chí Y Dược học Quân sự, 48(2), 73-80. https://doi.org/10.56535/jmpm.v48i2.279

STUDY ON THE PRESENCE OF OIPA AND DUPA GENES OF HELICOBACTER PYLORI IN GASTRIC CANCER PATIENTS

Pham Hong Khanh1, , Duong Quang Huy1, Nguyen quang Duat1, Tran Thi Huyen Trang2, Vu Van Khien2
1 Military Medical Hospital 103, Vietnam Military Medical University
2 Central Military Hospital 108

Nội dung chính của bài viết

Tóm tắt

Objectives: To determine the percentage of Helicobacter pylori (H. pylori) carrying the outer inflammatory protein A (oipA), duodenal ulcer promotion (dupA) genes, and their relationship with endoscopic imaging, histopathology, and the risk of gastric cancer (GC). Subjects and methods: A cross-sectional study on 89 GC patients, compared with 90 patients with chronic gastritis (CG) with H. pylori infection, diagnosis based on histopathological results at Military Hospital 103 and Central Military Hospital 108 from August 2019 to May 2022. Determination of oipA, dupA genes of H. pylori by realtime-PCR technique on biopsy tissue samples of the gastric mucosa. Results: The percentage of H. pylori carrying the oipA and dupA genes was 30.2% and 10.1%, respectively. The relationship between bacterial infection harboring these 2 genes and endoscopic images and histopathology of GC has not been recorded. There was no difference in the prevalence of H. pylori carrying the oipA and dupA genes infection between the GC and CG groups (p > 0.05). Conclusion: The infection of H. pylori with oipA and dupA genes positive may not increase GC risk in Vietnamese.

Chi tiết bài viết

Từ khóa

Helicobacter pylori, oipA, dupA, Ung thư dạ dày, Viêm dạ dày mạn

Tài liệu tham khảo

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