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Ngày xuất bản: 10/12/2025
Số lượt xem tóm tắt: 13
Số lượt xem PDF: 5
DOI: 10.56535/jmpm.v50si4.1385
Số xuất bản
Tập 50 Số si4 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ - SỐ ĐẶC BIỆT 12/2025
Chuyên mục
Số đặc biệt chào mừng kỷ niệm 75 năm Ngày truyền thống Bệnh viện Quân y 103
Trích dẫn bài báo
Nguyen, T. S., Nguyen, T. P. N., Nguyen, M. N., Le, D. T., Nguyen, H. T., Le, T. H. V., Dao, N. H., Dinh, T. H., & Vu, H. T. (2025). STUDY ON THE RELATIONSHIP OF MATERNAL SERUM CORTISOL AND LOW-GRADE INFLAMMATION INDICES WITH SOME PREECLAMPSIA RISKS AND FETAL GROWTH INDICES BY ULTRASOUND IN FIRST-TIME DIAGNOSED GESTATIONAL DIABETES MELLITUS. Tạp chí Y Dược học Quân sự, 50(si4), 646-653. https://doi.org/10.56535/jmpm.v50si4.1385

STUDY ON THE RELATIONSHIP OF MATERNAL SERUM CORTISOL AND LOW-GRADE INFLAMMATION INDICES WITH SOME PREECLAMPSIA RISKS AND FETAL GROWTH INDICES BY ULTRASOUND IN FIRST-TIME DIAGNOSED GESTATIONAL DIABETES MELLITUS

Nguyen Tien Son1, , Nguyen Thi Phi Nga1, Nguyen Minh Nui1, Le Dinh Tuan1, Nguyen Huy Thong1, Le Thi Hong Van2, Dao Nguyen Hung3, Dinh Trung Hoa3, Vu Hien Trinh3
1 Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University
2 Department of Obstetrics and Gynecology, Military Hospital 103, Vietnam Military Medical University
3 National Hospital of Endocrinology

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Tóm tắt

Objectives: To describe serum cortisol and low-grade inflammation (LGI) in first-time diagnosed gestational diabetes mellitus (GDM) and investigate the relationship of maternal serum cortisol and LGI with maternal preeclampsia risks and fetal growth indices by ultrasound in first-time diagnosed GDM.Methods: A cross-sectional, descriptive study was conducted on 248 first-time diagnosed GDM in Military Hospital 103 and National Hospital of Endocrinology from 2015 to 2024. Results: Serum cortisol, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were significantly higher in GDM compared with the normal glucose-tolerant (NGT) group. LGI but not cortisol levels were associated with percentage of age > 35, systolic blood pressure, and BMI. While maternal cortisol positively correlated with abdominal circumference - AC (r = 5.5) and estimated fetal weight - EFW (r = 85.3) of the fetus, NLR negatively correlated with EFW (B = -64.4) after adjusting for maternal BMI and FPG. PLR negatively correlated with fetal biparietal diameter - BPD (B = -0.02), AC (B = -0.06), EFW (B = -1.1), and head circumference - HC (B = -0.06), with p < 0.05. Conclusion: Serum cortisol, LGI, and fetal growth indices in GDM were higher than those in NGT pregnancy.

Từ khóa

Gestational diabetes mellitus, Cortisol, Low-grade inflammation, Fetal ultrasound index, Preeclampsia risk

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Tài liệu tham khảo

1. Kondracki AJ, Valente MJ, Ibrahimou B, Bursac Z. Risk of large for gestational age births at early, full and late term in relation to pre‐pregnancy body mass index: Mediation by gestational diabetes status. Paediatr Perinat Epidemiol.2022; 36:566-576.
2. Pace NP, Vassallo J. Association between neutrophil-lymphocyte ratio and gestational diabetes-a systematic review and meta-analysis. J Endocr Soc. 2021; 5.
3. Lee C, Lee SM, Byun DJ, et al. Maternal signatures of cortisol in first trimester small-for-gestational age. Reprod Sci. 2022; 29:1498-1505.
4. Entringer S, Buss C, Rasmussen JM, et al. Maternal cortisol during pregnancy and infant adiposity: A prospective investigation. J Clin Endocrinol Metab. 2016; 3025.
5. Osimo EF, Baxter LJ, Lewis G, et al. Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels. Psychol Med. 2019; 49:1958-1970.
6. Tyas BD, Lestari P, Aldika Akbar MI. Maternal perinatal outcomes related to advanced maternal age in preeclampsia pregnant women. J Fam Reprod Heal. 2019; 13:191-200.
7. Feng Y, Feng Q, Lv Y, et al. The relationship between iron metabolism, stress hormones, and insulin resistance in gestational diabetes mellitus. Nutr Diabetes. 2020; 10:17.
8. Aktulay A, Engin-Ustun Y, Ozkan MS, et al. Gestational diabetes mellitus seems to be associated with inflammation. Acta Clin Croat. 2015; 54:475-478.
9. Crowther CA, Middleton PF, Voysey M, et al. Effects of repeat prenatal corticosteroids given to women at risk of preterm birth. An individual participants data meta-analysis. PloS Med. 2019; 16:e1002771.
10. Shafiq M, Mathad JS, Naik S, et al. Association of maternal inflammation during pregnancy with birth outcomes and infant growth among women with or without HIV in India. JAMA Netw Open. 2021; 4:e2140584.