CORRELATION BETWEEN AMH LEVEL AND NUMBER OF OOCYTES, EMBRYOS OBTAINED BY AGE GROUPS IN PATIENTS UNDERGOING IN VITRO FERTILIZATION COMBINED WITH PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY

Tóm tắt

Objectives: To evaluate the correlation between the concentration of AMH (Anti-mullerian hormone) with the number of oocytes and embryos obtained in general and in each maternal age group, in particular on infertile patients undergoing in vitro fertilization (IVF) combined with preimplantation genetic testing for aneuploidy (PGT-A). Subjects and methods: A prospective, descriptive study of 186 infertile patients undergoing IVF - PGT-A, divided into three groups according to their ages at delivery: Group I: less than 30 years; group II: 30-35 years; group III: over 35 years. Results: Generally, AMH level was positively correlated with the number of oocytes and embryos obtained with r of 0.301; 0.193, respectively. At the age of less than 30, there was no statistically significant correlation between AMH and the number of oocytes and embryos (p > 0.05); in group II: AMH had a significant positive correlation with the number of oocytes obtained (r = 0.248, p < 0.05); in group III: AMH had a positive correlation with both the number of oocytes and the number of embryos with r of 0.385; 0.412, respectively (p < 0.05). Conclusion: The general AMH concentration in patients undergoing IVF - PGT-A was statistically significantly positively correlated with the number of oocytes and embryos obtained. In patients 30 - 35 years old, AMH level was significantly weak positively correlated with the number of mature oocytes. In the group over 35 years old, AMH level was statistically significantly positively correlated with the number of oocytes and the number of obtained blastocysts. No significant correlation was found between AMH levels and the number of oocytes or blastocysts in the age group under 30.