STUDY ON PLASMA LEPTIN LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS WITH OVERWEIGHT OR OBESITY
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Tóm tắt
Objectives: To investigate plasma leptin level and its association with some risk factors in type 2 diabetes mellitus (T2DM) patients with overweight or obesity. Subjects and methods: A cross-sectional descriptive and comparable study was conducted on 266 patients assigned into three groups, including T2DM patients with overweight or obesity (study group, n = 104), non-overweight/non-obese atients with T2DM (disease-control, n = 109) and healthy control subjects (n = 53). Plasma leptin levels were quantified with ELISA Kit at the Department of Pathophysiology, Vietnam Military Medical University. Results: For type 2 diabetic patients with obesity/overweight, we found no significant difference in plasma leptin levels between the study group and the disease-control and healthy subjects (0.43; 0.35-0.53 ng/mL vs 0.42; 0.34-0.52 ng/mL and 0.46; 0.36-0.60 ng/mL, respectively) with p > 0.05. In the overweight or obese diabetic patients, there was a positive correlation of leptin levels with age (r = 0.228; p = 0.02), waist circumference (WC) (r = 0.638; p < 0.001), hip circumference (HC) (r = 0.473; p < 0.001), W/H (r = 0.471; p < 0.001) and serum creatinine levels (r = 0.508; p < 0.001). Additionally, plasma leptin levels were higher in overweight/obese patients who were diabetic for more than 5 years (0.47 ± 0.16 ng/mL) than in those with diabetes less than 5 years (0.38 ± 0.15 ng/mL) (p < 0.05). Significantly higher blood leptin levels were noted in the group with hypertension than in normotensive individuals (p < 0.05).
Từ khóa
Type 2 diabetes mellitus, Plasma leptin level, Overweight, Obesity
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Tài liệu tham khảo
2. Thái Hồng Quang (2012). Thực hành lâm sàng bệnh đái tháo đường, Nhà xuất bản Y học, Hà Nội, 53-165.
3. Katsiki N., Mikhailidis D.P., Banach M. (2018). Leptin, cardiovascular diseases and type 2 diabetes mellitus. Acta Pharmacol Sin; 39(7):1176-1188.
4. Tups A. (2009). Physiological models of leptin resistance. J Neuroendocrinol; 21(11):961-71.
5. Allison M.A., Bluemke D.A., McClelland R., et al. (2013). Relation of leptin to left ventricular hypertrophy (from the Multi-Ethnic Study of Atherosclerosis). Am J Cardiol; 112(5):726-30.
6. Võ Minh Phương (2019). Nghiên cứu nồng độ leptin, adiponectin huyết tương và tỷ lệ leptin/adiponectin trên đối tượng thừa cân - béo phì. Luận án Tiến sĩ Y học. Học viện Quân y.
7. Meier U., Gressner A.M. (2004). Endocrine regulation of energy metabolism: Review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem; 50(9):1511-25.
8. Van Gaal, L.F., Wauters M.A., Mertens I.L., et al. (1999). Clinical endocrinology of human leptin. Int J Obes Relat Metab Disord; 23 Suppl 1:29-36.
9. Werida R., Khairat I., Khedr N.F. (2021). Effect of atorvastatin versus rosuvastatin on inflammatory biomarkers and LV function in type 2 diabetic patients with dyslipidemia. Biomed Pharmacother; 135:1-8.
10. Montserrat-de la Paz S., Pérez-Pérez A., Vilariño-García T., et al. (2021). Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications. J Nutr Biochem; 89:1-7.
11. Alzamil H. (2020). Elevated serum TNF-α is related to obesity in type 2 diabetes mellitus and is associated with glycemic control and insulin resistance. J Obes; 2020:1-7.
12. Shih Y.L., Shih C.C., Chen S.Y., et al. (2022). Elevated serum leptin levels are associated with lower renal function among middle-aged and elderly adults in Taiwan, a community-based, cross-sectional study. Front Endocrinol (Lausanne); 13:1-8.