THE ASSOCIATION BETWEEN PERIPHERAL BLOOD NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TO-LYMPHOCYTE RATIOS WITH CLINICAL AND LABORATORY CHARACTERISTICS IN PATIENTS WITH HEPATOCELLULAR CARCINOMA
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Tóm tắt
Objectives: To analyze the association between peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) with clinical and laboratory characteristics in patients with hepatocellular carcinoma (HCC). Methods: A cross-sectional descriptive study was conducted on 60 newly diagnosed HCC patients who had not received any treatment. These patients came for examination and treatment at the Department of Gastroenterology and Hepatology, Military Hospital 103, from April 2023 to April 2024. Results: The patients had a mean age of 61.5 years, predominantly male (96.7%), with a median tumor size of 6.4cm, and 21.7% presented with metastasis. The median value of AFP was 965.3 ng/mL, CRP was 13.8 ng/mL, ALBI score was -2.06, NLR was 2.6, and PLR was 104.9. No significant differences in NLR or PLR were observed across subgroups by age, liver function, tumor number/size, or metastasis. NLR correlated positively with AST (r = 0.41), CRP (r = 0.51), ALBI score (r = 0.36), and negatively with albumin (r = -0.38) and prothrombin ratio (r = -0.31), while PLR showed only a weak positive correlation with CRP (r = 0.28). Conclusion: NLR and PLR were associated with markers of liver injury and systemic inflammation. NLR showed moderate correlations with AST, CRP, ALBI score, albumin, and prothrombin ratio, whereas PLR demonstrated only a weak correlation with CRP.
Từ khóa
Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, Hepatocellular carcinoma, Clinical and laboratory characteristics
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