CHARACTERISTICS OF PROTEINURIA AND ITS RELATIONSHIP WITH THE PRESENCE OF ANTI-HLA ANTIBODIES AFTER TRANSPLANTATION IN PATIENTS WITH RENAL ALLOGRAFT DYSFUNCTION DURING THE FIRST 6 MONTHS OF FOLLOW-UP

Tóm tắt

Objectives: To investigate the characteristics of proteinuria and its association with the presence of anti-HLA antibodies following kidney transplantation in patients with renal allograft dysfunction during the first 6 months of follow-up at Military Hospital 103. Methods: A prospective, descriptive, longitudinal study was conducted on 51 patients who underwent kidney transplantation from living donors and exhibited renal allograft dysfunction during the first 6 months post-transplantation, from June 2019 to January 2021. Results: Proteinuria occurred in 33.3% of patients within the first 6 months, with the highest incidence observed at the end of the first month (19.6%). Post-transplant panel-reactive antibody (PRA) positivity was found in 78.4% of patients. Among these, 17 out of 51 patients (33.3%) tested positive for donor-specific anti-HLA antibodies (HLA-DSA). The incidence of proteinuria, both overall and at specific time points (the 1^st month and 6^th month), was significantly higher in the HLA-DSA (+) group compared to the HLA-DSA (–) group (p < 0.05). However, no significant association was observed between proteinuria and the presence of anti-HLA-DP or anti-HLA-DQ antibodies. The presence of HLA-DSA post-transplantation was strongly associated with the development of proteinuria (OR = 30.36; p < 0.01). Conclusion: Proteinuria was observed in 33.3% of patients during the first 6 months after kidney transplantation. The presence of HLA-DSA was significantly associated with the occurrence of proteinuria post-transplantation (OR = 30.36; p < 0.01).