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Ngày xuất bản: 28/04/2025
Số lượt xem tóm tắt: 46
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DOI: https://doi.org/10.56535/jmpm.v50i4.1180
Số xuất bản
Tập 50 Số 4 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 4 - 2025
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Nguyen, H. H., Do, D. T., & Do, X. H. (2025). RESULTS OF ALZHEIMER’S DISEASE ANIMAL MODEL INDUCTION BASED ON THE INTRAHIPPOCAMPAL INJECTION OF AMYLOID Β-PEPTIDE (1-42) AT VIETNAM MILITARY MEDICAL UNIVERSITY. Tạp chí Y Dược học Quân sự, 50(4), 22-31. https://doi.org/10.56535/jmpm.v50i4.1180

RESULTS OF ALZHEIMER’S DISEASE ANIMAL MODEL INDUCTION BASED ON THE INTRAHIPPOCAMPAL INJECTION OF AMYLOID Β-PEPTIDE (1-42) AT VIETNAM MILITARY MEDICAL UNIVERSITY

Nguyen Ha Hoa1, , Do Duc Thuan1, Do Xuan Hai2
1 Department of Neurology, Vietnam Military Medical University
2 Practical and Experimental Surgery Department, Vietnam Military Medical University

Nội dung chính của bài viết

Tóm tắt

Objectives: To evaluate some behaviors and histological results of the hippocampus in a rat model of Alzheimer's disease (AD). Methods: A longitudinal, descriptive study was conducted on 21 Wistar rats. Intrahippocampal amyloid beta (Aβ) injection was performed, followed by behavioral testing and analysis and hippocampal histological examination. Results: Rats in the AD model showed learning impairment with a reduced average latency time (52.09 ± 10.67s) and reduced latency time on the 5th day (27.08 ± 6.88s) during the learning phase of the Morris water maze (MWM) test. Memory impairment was indicated by a decreased percentage of spontaneous alternations (34.45 ± 7.03%) in the Y-maze test, reduced time spent (14.84 ± 4.61s), and shorter distance traveled (2.26 ± 0.82m) in the target quadrant during the probe trial of the MWM test. Neurodegeneration in the hippocampus was observed, with an increased degeneration score (1.83 ± 0.31). Conclusion: Intrahippocampal Aβ injection is an effective method for inducing the AD model in rats, characterized by learning and memory impairments as well as neurodegeneration in experimental animals.

Chi tiết bài viết

Từ khóa

Alzheimer's disease model, Hippocampus, Stereotaxic surgery

Tài liệu tham khảo

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