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Ngày xuất bản: 28/04/2025
Số lượt xem tóm tắt: 97
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DOI: https://doi.org/10.56535/jmpm.v50i4.1180
Số xuất bản
Tập 50 Số 4 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 4 - 2025
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Nguyen, H. H., Do, D. T., & Do, X. H. (2025). RESULTS OF ALZHEIMER’S DISEASE ANIMAL MODEL INDUCTION BASED ON THE INTRAHIPPOCAMPAL INJECTION OF AMYLOID Β-PEPTIDE (1-42) AT VIETNAM MILITARY MEDICAL UNIVERSITY. Tạp chí Y Dược học Quân sự, 50(4), 22-31. https://doi.org/10.56535/jmpm.v50i4.1180

RESULTS OF ALZHEIMER’S DISEASE ANIMAL MODEL INDUCTION BASED ON THE INTRAHIPPOCAMPAL INJECTION OF AMYLOID Β-PEPTIDE (1-42) AT VIETNAM MILITARY MEDICAL UNIVERSITY

Nguyen Ha Hoa1, , Do Duc Thuan1, Do Xuan Hai2
1 Department of Neurology, Vietnam Military Medical University
2 Practical and Experimental Surgery Department, Vietnam Military Medical University

Nội dung chính của bài viết

Tóm tắt

Objectives: To evaluate some behaviors and histological results of the hippocampus in a rat model of Alzheimer's disease (AD). Methods: A longitudinal, descriptive study was conducted on 21 Wistar rats. Intrahippocampal amyloid beta (Aβ) injection was performed, followed by behavioral testing and analysis and hippocampal histological examination. Results: Rats in the AD model showed learning impairment with a reduced average latency time (52.09 ± 10.67s) and reduced latency time on the 5th day (27.08 ± 6.88s) during the learning phase of the Morris water maze (MWM) test. Memory impairment was indicated by a decreased percentage of spontaneous alternations (34.45 ± 7.03%) in the Y-maze test, reduced time spent (14.84 ± 4.61s), and shorter distance traveled (2.26 ± 0.82m) in the target quadrant during the probe trial of the MWM test. Neurodegeneration in the hippocampus was observed, with an increased degeneration score (1.83 ± 0.31). Conclusion: Intrahippocampal Aβ injection is an effective method for inducing the AD model in rats, characterized by learning and memory impairments as well as neurodegeneration in experimental animals.

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Từ khóa

Alzheimer's disease model, Hippocampus, Stereotaxic surgery

Tài liệu tham khảo

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