Thanh bên bài viết

PDF
Ngày xuất bản: 28/04/2025
Số lượt xem tóm tắt: 17
Số lượt xem PDF: 10
DOI: https://doi.org/10.56535/jmpm.v50i4.1119
Số xuất bản
Tập 50 Số 4 (2025): TẠP CHÍ Y DƯỢC HỌC QUÂN SỰ SỐ 4 - 2025
Chuyên mục
Bài báo
Trích dẫn bài báo
Ho, B. N. M., Nguyen, T. D., Pham, V. H., & Vu, B. D. (2025). ESTABLISHMENT OF THE 6-SHOGAOL EXTRACTION PROCESS FROM 6-SHOGAOL-ENRICHED GINGER FOR CANCER TREATMENT. Tạp chí Y Dược học Quân sự, 50(4), 5-13. https://doi.org/10.56535/jmpm.v50i4.1119

ESTABLISHMENT OF THE 6-SHOGAOL EXTRACTION PROCESS FROM 6-SHOGAOL-ENRICHED GINGER FOR CANCER TREATMENT

Ho Ba Ngoc Minh1, Nguyen Trong Diep1, Pham Van Hien1, Vu Binh Duong1,
1 Vietnam Military Medical University

Nội dung chính của bài viết

Tóm tắt

Objectives: To optimally extract the potential phytochemical “6-shogaol” from fermented shogaol-enriched ginger. Methods: Extraction process parameters were investigated using 6-shogaol as a marker. Results: The suitable parameters of the 6-shogaol extraction process: Hot extraction using reflux equipment, solvent of 90% ethanol, solvent/herb ratio of 15/1, temperature of 70ºC, duration of 90 minutes, and two-time extraction. The 6-shogaol extraction efficiency was 89.61 ± 0.68%. Conclusion: The optimal process for 6-shogaol extraction from fermented shogaol-enriched ginger has been studied.

Chi tiết bài viết

Từ khóa

6-shogaol, Extraction process, 6-shogaol-enriched ginger

Tài liệu tham khảo

1. Sang S, Hong J, Wu H, et al. Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. J. Agric. Food Chem. 2009; 57(22):10645-10650. DOI: 10.1021/jf9027443.
2. Zhang M, Viennois E, Prasad M, et al. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials. 2016; 101:321-340. DOI: 10.1016/j.biomaterials.2016.06.018.
3. Citronberg J, Bostick R, Ahearn T, et al. Effects of ginger supplementation on cell-cycle biomarkers in the normal-appearing colonic mucosa of patients at increased risk for colorectal cancer: Results from a pilot, randomized, and controlled trial. Cancer Prev. Res. 2013; 6:271-281. DOI: 10.1158/1940-6207.capr-12-0327.
4. Y-J Surh. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: A short review. Food and Chemical Toxicology. 2002; 40(8):1091- 1097. DOI: 10.1016/s0278-6915(02)00037-6.
5. RD Altman and KC Marcussen. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis & Rheumatism. 2001; 44(11): 2531-2538. DOI: 10.1002/1529-0131 (200111)44:11<2531::aid-art433>3.0.co;2-j.
6. Hsu YL, Hung JY, Tsai YM, et al. 6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion of CC-chemokine ligand 2 (CCL2) in tumor-associated dendritic cells. J. Agric. Food Chem. 2015; 63(6):1730-1738. DOI: 10.1021/jf504934m.
7. Ok S and Jeong WS. Optimization of extraction conditions for the 6-shogaol-rich extract from Ginger (Zingiber officinale Roscoe). Prev. Nutr. Food Sci. 2012; 17(2):166-171. DOI: 10.3746/pnf.2012.17.2.166.
8. JO, Soo Kyung, et al. Characterization of metabolites produced from the biotransformation of 6-shogaol formed by Aspergillus niger. European Food Research and Technology. 2016; 242:137-142. DOI: 10.1007/s00217-015-2519-6.
9. Kou X, Wang X, Ji R, Liu L, Qiao Y, Lou Z, Ma C, Li S, Wang H, Ho CT. Occurrence, biological activity, and metabolism of 6-shogaol. Food Funct. 2018; 9 (3):1310-1327. DOI: 10.1039/ c7fo01354j.
10. X-L Cheng, Q Liu, Y-B Peng, L-W Qi, and P Li. Steamed ginger (Zingiber officinale): Changed chemical profile and increased anticancer potential. Food Chemistry. 2011; 129(4):1785-1792. DOI: 10.1016/j.foodchem.2011.06.026.