LIVER BIOCHEMICAL CHANGES IN PATIENTS AFTER DIFFERENTIATED THYROID CANCER SURGERY AND BEFORE RADIOIODINE THERAPY

Tóm tắt

Objectives: To investigate liver enzyme changes and assess liver function in patients with differentiated thyroid cancer who have undergone surgery and are preparing for radioiodine therapy (¹³¹I therapy). Methods: A cross-sectional descriptive study on 163 patients with differentiated thyroid cancer 4 - 6 weeks after surgery at the Military Institute of Radiation Medicine and Oncology from April 2023 to April 2024. Evaluating liver enzymes and liver function at the time of preparing for ¹³¹I therapy, compared with a number of paraclinical parameters to find factors related to liver damage. Results: 38.0% of patients had liver damage (increased AST or ALT), of which 35.6% increased AST, and 24.5% increased ALT, mainly mildly increased (40 to < 100 U/L) and a low rate of liver dysfunction (5.5% slight increase in total Bilirubin and 11.0% decrease in Prothrombin ratio). Male gender and decreased FT4 concentration < 1.17 pmol/L were two factors related to liver damage with ORs of 2.56 and 2.74, respectively, p < 0.01. Conclusion: Liver damage is a relatively common phenomenon related to male gender and FT4 levels in patients with thyroid cancer after surgery and being prepared for ¹³¹I therapy.